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在全身性红斑狼中,疾病活动的潜在生物标志物是全身性免疫炎症指数

Muhammed Recai Akdogan¹, Meltem Alkan Melikoglu²

¹Division of Rheumatology, Department of Internal Medicine, Ataturk University Faculty of Medicine, Erzurum, Turkiye.

Northern clinics of Istanbul

|May 17, 2024

概括

常规的实验室测试,如中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和全身免疫炎症指数 (SII),可以帮助评估全身狼 (SLE) 疾病的活性. 特别有希望的SII显示为区分SLE疾病严重程度的生物标志物.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
临床诊断临床诊断临床诊断

背景情况:

系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,需要精确监测疾病活动.
从常规实验室测试中获得的生物标志物为SLE的临床管理提供了实际优势.

研究的目的:

评估中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和全身免疫炎症指数 (SII) 作为SLE疾病活动的潜在生物标志物.
将这些指数与SLE活动的临床和实验室标志物相关联.

主要方法:

一项病例对照研究,将SLE患者与健康对照进行比较.
使用SLEDAI评分评估SLE疾病活动.
从完整血清 (CBC) 数据中计算NLR,PLR和SII.
在CBC指数和已确定的SLE标志物 (ESR,CRP,C3-C4,抗dsDNA) 之间的相关性分析.

主要成果:

与对照组相比,NLR,PLR和SII在SLE患者中显著增加.
在SLEDAI得分和NLR,PLR和SII之间观察到正相关性.
一个SII截止值681.3显示77%的灵敏度和76%的特异性在区分SLE疾病活动水平.

结论:

完整血清 (CBC) 指数,特别是SII,在SLE患者中升高.
SII与SLE疾病活动有很强的相关性,可以区分疾病状态.
SII具有作为一个有价值的生物标志物的潜力,以支持SLE管理中的临床评估.

关键词:

生物标志物生物标志物疾病活动的疾病活动.中性粒细胞与淋巴细胞的比率.血小板与淋巴细胞的比率.系统性免疫炎症指数系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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