治疗儿科关键性喘的阿齐思罗米:一个多中心的回顾性队列研究
Alexa R Roberts1, Nikhil Vallabhaneni2, Brett Russi1
1Divisions of Pediatric Critical Care Medicine.
Hospital pediatrics
|May 17, 2024
概括
对于儿科关键性喘 (CA) 的阿齐思罗米辛 (AZI) 处方从2011年到2022年减少. 接受AZI的儿童患病更严重,住院时间更长,尽管缺乏这种使用的疗效数据.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 药理学和治疗学 药理学和治疗学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 阿齐思罗米 (AZI) 有时用于儿科关键性喘 (CA),但其在这个人群中的使用和影响并未得到很好的描述.
- 对于AZI在因CA住院的儿童中缺乏来自试验的疗效和安全性数据.
研究的目的:
- 分析在患有严重喘 (CA) 的住院儿童中阿齐思罗米 (AZI) 处方趋势.
- 评估与这种儿科患者群体中AZI使用相关的临床结果.
主要方法:
- 使用儿科健康信息系统注册表进行了一项多中心的回顾性队列研究.
- 分析了2011年1月至2022年12月期间因CA住院的3至17岁儿童的数据.
- 排除标准针对AZI的替代适应症;结果包括处方率,患者人口统计,CA治疗和住院治疗结果.
主要成果:
- 在47797名患有CA的儿童中,阿齐思罗米被处方给了20.7%的儿童,显示了从2011年的34.7%下降的趋势,到2022年的12.4%.
- 接受AZI治疗的儿童年龄较大,临床过程更为严重,这体现在气道压力,侵入性通风,体外生命支持和更长时间住院的比率较高.
- 机构AZI处方率的中位数差异很大,从5.6%到60%不等.
结论:
- 尽管没有支持的疗效或安全性数据,但在2011年至2022年期间,阿齐思罗米被处方给了大量因严重喘住院的儿童.
- 观察到的趋势表明,在研究期间,AZI的处方减少了.
- 接受AZI的儿童表现出更严重的疾病轨迹,强调需要进一步调查其适宜性和对儿科严重喘的影响.
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