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孕期的大脑损伤继续影响早产期青少年的DTI参数:一项为期13年的随访研究

Sirkku Setänen¹, Harri Merisaari^2,3, Virva Saunavaara^4,5

¹Department of Pediatric Neurology, University of Turku and Turku University Hospital, Turku, Finland.

Acta radiologica (Stockholm, Sweden : 1987)

|May 17, 2024

概括

早产婴儿的大脑损伤会影响白质的成熟,在青春期对扩散张力成像 (DTI) 参数,如分数异形度 (FA) 和平均扩散度 (MD) 产生持久影响.

科学领域:

神经成像是一种神经成像.
发育神经科学的发展神经科学.
儿科神经学儿科神经学

背景情况:

非常早产婴儿的大脑损伤会影响期内扩散张力成像 (DTI) 参数.
白质成熟的特点是,随着妊娠年龄的增长,分数异构性 (FA) 和平均扩散性 (MD) 的降低.

研究的目的:

为了比较DTI参数 (FA和MD) 在期和13岁的青少年出生非常早产.
调查有或没有主要结构性脑MRI病理的青少年之间的差异.

主要方法:

包括24名非常早产的青少年 (妊娠年龄<32周和/或出生体重≤1500克).
在18个感兴趣的地区使用JHU-neonate-SS图谱评估了期限和13年的FA和MD.
青少年之间DTI参数的比较,有和没有在术后MRI上发现的大脑损伤.

主要成果:

患有严重脑损伤的青少年 (n=6) 在13岁时显示左脑体和右带带状回形中减少了FA.
在那些受伤的人群中,在左体,内的右前肢和内的右后肢中观察到MD的增加.
这些差异与没有严重脑损伤的青少年进行了比较 (n=18).

结论:

长期在结构性MRI上发现的大脑损伤显著影响大脑成熟.
对FA和MD的不良影响持续到青春期,表明长期的神经影响.

关键词:

在JHU-新生儿-SSSS.分数异构性是分数异构性的.长期的后续监测.磁共振成像技术的使用平均扩散性是指神经发育的神经发育

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