Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Oral Microbiota01:27

The Oral Microbiota

90
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
90
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

77
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
77
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

98
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
98
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

233
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
233
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

34
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
34

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Ontogenetic skull variation in a round-headed Trogonophidae amphisbaenian species with inferences on bite force.

Anatomical record (Hoboken, N.J. : 2007)·2026
Same author

Influence of Heat Treatment on the Shaping Ability of Rotary Instruments in Severely Curved Root Canals: A Stepwise Analysis.

European endodontic journal·2026
Same author

Renal expression of Bach1 and oxidative stress in chronic kidney disease: evidence from a preclinical model.

Jornal brasileiro de nefrologia·2026
Same author

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence.

Journal of periodontal research·2026
Same author

Impact of Different Irrigation Needles on Debris Removal in Mesial Canals of Mandibular Molars After Conservative Preparation.

European endodontic journal·2026
Same author

Effects of highly leukotoxic Aggregatibacter actinomycetemcomitans associated with ligature-induced periodontitis on oral and gut tissues in male rats.

Journal of applied oral science : revista FOB·2026

相关实验视频

Updated: May 5, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

17.6K

牙周病原体Aggregatibacter actinomycetemcomitans JP2与大肠白细胞减少和小鼠肠道微生物组失衡相关.

André L A da Costa1,2, Mariana A Soares3, Talita G B Lourenço1

  • 1Oral Microbiology Laboratory, Institute of Microbiology Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Journal of periodontal research
|May 17, 2024
PubMed
概括

口腔病原体Aggregatibacter actinomycetemcomitans (Aa) 改变肠道微生物群,并减少小鼠的免疫细胞. 这种口腔肠轴的干扰显示了病原生物的增加和开始的减少,没有显著的肠道炎症.

关键词:
聚合细菌的行为性菌 (Aggregatibacter actinomycetemcomitans JP2 JP2) 已经被发现.肠道失调症是一种肠道失调症.我们的肠道微生物组.恒常状态 (homeostasis) 是一种平衡状态.在口腔肠轴上.牙周病原体是牙周病原体.

更多相关视频

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

12.1K
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.4K

相关实验视频

Last Updated: May 5, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

17.6K
Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

12.1K
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.4K

科学领域:

  • 微生物学 微生物学
  • 免疫学 免疫学 免疫学
  • 胃肠病学 胃肠病学

背景情况:

  • 口腔病原体可能会转移到肠道,可能会通过口腔-肠轴引起肠道失调.
  • 高度白血病毒性的Aggregatibacter actinomycetemcomitans (Aa) 菌株与牙周病有关.

研究的目的:

  • 为了研究高度白血毒性Aa菌株 (JP2) 对肠道微生物群,肠道粘膜完整性和健康小鼠免疫系统的影响.
  • 评估口腔病原体转移对肠道生态系统的影响.

主要方法:

  • 八周大的雄性C57BL6小鼠在4周内接受了Aa JP2或PBS的输入.
  • 分析包括结肠膜本身,便物质,血清,牙组织和下.
  • 评估的参数:白细胞种群,炎症媒介,粘膜完整性,膜骨损失和肠道微生物群.

主要成果:

  • Aa JP2感染减少了肠道微生物的丰富性和结肠髓状细胞 (巨细胞,中性粒细胞,单细胞).
  • 在受感染的小鼠中观察到Clostridiaceae,Lactobacillus taiwanensis和Helicobacter rodentium的丰富性增加.
  • 受感染的小鼠表现出更高的结肠IL-6表达,脏MPO活性和轻微的膜骨损失.

结论:

  • 胃内 Aa JP2 的使用会改变健康小鼠的肠道生态系统.
  • 变化包括减少了髓状细胞,富含病原生物的丰富,并减少了共生动物.
  • 没有观察到粘膜屏障或结肠炎症的显著破坏.