在患有正常血糖,糖尿病前期和2型糖尿病的人群中,MAFLD和球过:一个横截面人口研究
Manuela Abbate1,2,3, Aneliya Parvanova4, Ángel Arturo López-González5,6
1Research Group on Global Health, University of the Balearic Islands, Palma, Spain.
Diabetes/metabolism research and reviews
|May 17, 2024
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与增加的淋巴细胞过有关. MAFLD还加速了所有葡萄糖耐受水平的与年龄相关的功能下降.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与球过的风险因素是相同的,包括肥胖和糖尿病.
- MAFLD是一个日益关注的问题,具有显著的代谢影响.
研究的目的:
- 为了确定MAFLD患病率与球过的关系.
- 为了研究MAFLD与功能下降之间的关联,在不同的葡萄糖耐受性状态 (常态血糖,糖尿病前期,2型糖尿病) 中进行研究.
主要方法:
- 分析了来自18-65岁的125,070名西班牙公务员的职业健康数据.
- 基于空腹血葡萄糖水平的分类和使用CKD-EPI方程式估计的球过率 (eGFR).
- 多变量逻辑回归以评估MAFLD和过 (eGFR高于年龄和性别特定的95百分位) 之间的关联.
主要成果:
- 总体而言,MAFLD的患病率为19.3%,随着葡萄糖耐受性恶化,患病率显著增加 (14.7%至48.9%).
- 在所有组中,MAFLD与过严重相关 (整体调整后OR为9.06).
- 在所有血糖类别中,MAFLD显著放大了年龄相关的EGFR下降.
结论:
- 随着葡萄糖水平的增加,MAFLD的患病率会上升.
- MAFLD是球膜过的一个重要危险因素.
- MAFLD会加剧与年龄相关的功能下降.
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