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Updated: Jul 30, 2026

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毒素的复制被MMV676477抑制,而不会产生抗药性

Izra Abbaali1, Danny Truong1, Dawn M Wetzel2

  • 1Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.

Cytoskeleton (Hoboken, N.J.)
|May 17, 2024
PubMed
概括

一种新型化合物,MMV676477,通过向原生类管氨酸,有效地抑制了寄生虫Toxoplasma gondii的生长. 这种药物对治疗寄生虫感染具有很低的耐药性发展风险.

关键词:
同型的类型是同型.微管向剂是微管向剂中的一种.突变发生的突变发生.治疗指数 治疗指数

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Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...