在现场使用磁共振光谱温度计进行温度测定,用于非侵入性尸检
Niklaus Zoelch1,2, Jakob Heimer1, Henning Richter3
1Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.
磁共振光谱 (MRS) 温度计准确地估计了死后的大脑温度,使用乳酸作为参考代谢物. 这种非侵入性技术对于法医是可靠的,即使在延长的死后间隔.
科学领域:
- 法医科学 法医科学 法医科学
- 医疗成像医学成像
- 生物物理学的生物物理.
背景情况:
- 磁共振光谱仪 (MRS) 温度计使用水的化学转移来非侵入性地估计温度.
- 它在死后检查中的应用对调整MRI协议和数据分析充满希望.
- 死后的变化和常见的参考代谢物如N-乙酸的减少带来了挑战.
研究的目的:
- 评估乳酸酸作为死后MRS温度计的参考代谢物的适用性.
- 在死亡后60小时内对死后脑组织评估MRS温度计的准确性和可靠性.
- 在临床法医环境中与已故个体验证MRS温度计.
主要方法:
- 使用乳酸盐,一种在化学转换死后稳定的代谢物,作为MRS温度计的参考.
- 校准的MRS温度计使用已确立的体内方法.
- 用MR兼容的温度探头和羊头和人类受试者的直肠温度比较MRS温度结果.
主要成果:
- 使用乳酸的MRS温度计在死后的绵羊大脑组织中达到高精度 (平均绝对误差<0.5°C),死后60小时.
- 尽管分解,但在MRS温度计和直接温度测量之间没有观察到显著的偏差.
- 在84名已故个体中,MRS温度计提供了可信的大脑温度,即使在死后60小时内也显示出可靠性.
结论:
- 乳酸盐是准确的死后MRS温度计的合适参考代谢物.
- MRS温度计是法医和病理学中温度估计的可靠和非侵入性工具.
- 该技术显示出对死后MR检查的良好潜力,有助于温度调整和数据纠正.
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