患有差异化甲状腺癌和远程转移的患者的生存预测:一项基于SEER的人口研究
Debbie W Chen1, Grant Carr2, Francis P Worden3
1Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
概括
这项研究确定了差异化甲状腺癌患者与远程转移的不同预后组. 关键的生存因素包括患者年龄,肺转移和瘤大小,有助于风险分层.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 流行病学 流行病学
背景情况:
- 差异化甲状腺癌 (DTC) 的远程转移预示着不良结果.
- 由于稀有性 (<10%),DTC中转移的生存相关值未得到研究.
研究的目的:
- 在DTC患有远程转移的患者中确定预后组.
- 确定患者和瘤特征在生存中的作用和相互作用.
主要方法:
- 使用美国SEER-17癌症注册 (2010-2019) 对于患有远程转移的成年DTC患者.
- 采用Cox比例危险回归,生存树和随机生存森林进行分析.
- 评估患者和瘤因素对疾病特异性存活率 (DSS) 和整体存活率 (OS) 的相对重要性.
主要成果:
- 队列:2411名DTC患有远程转移的患者;中位数随访时间:62个月.
- 重要生存因素:患者年龄,瘤大小和转移部位 (特别是肺部).
- 确定了3个DSS组 (5年生存率:92%,64%,41%) 和4个OS组 (5年生存率:96%,84%,57%,31%).
- 诊断时的年龄是生存树的主要分类,其次是肺转移和瘤大小.
结论:
- 为DTC患有远程转移的患者建立了不同的预后组.
- 突出患者年龄,肺转移和瘤大小作为生存的关键决定因素.
- 研究结果支持改善了这种患者群体的风险分层和治疗决策.
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