器官凝:"GelVolution"在局部药物输送中 - 现在和以后
Ajinkya Nitin Nikam1, Amrita Roy1, Ruchira Raychaudhuri1
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.
Current pharmaceutical design
|May 17, 2024
概括
器官凝为皮肤病治疗提供先进的局部药物输送,改善药物溶解性,皮肤透和受控释放. 这些非油性配方在治疗癌症和感染等皮肤疾病方面具有显著的潜力.
科学领域:
- 皮肤病学 皮肤病学
- 材料科学 材料科学 材料科学
- 药品制造 药品制造 药品制造
背景情况:
- 局部药物输送对于非侵入性皮肤病治疗至关重要.
- 器官凝正在成为提高局部药物递送效率的有效系统.
- 关键优势包括改善药物溶解性,控制释放和增强皮肤透.
研究的目的:
- 审查用于局部药物输送的有机凝的优势和配方策略.
- 讨论器官凝透的机制及其生物医学应用.
- 为了检查表征,安全性,和未来的方向,用于organogel发展.
主要方法:
- 关于有机凝配方,特性和应用的文献综述.
- 在有机凝系统中讨论凝剂,凝剂和添加剂.
- 对有机凝特性,生物相容性和安全性数据的分析.
主要成果:
- 器官凝提供增强的药物溶解性,可控释放,并改善皮肤透.
- 配方策略包括仔细选择组件,并考虑温度和pH等环境因素.
- 器官凝具有多种生物医学应用,包括抗癌,抗炎和抗真菌疗法.
结论:
- 器官凝代表了皮肤病应用局部药物输送的重大进步.
- 对优化透,稳定性和监管方面的进一步研究将提高它们的临床实用性.
- 器官凝对于创新的皮肤治疗有着巨大的潜力.
相关概念视频
01:16Drug Delivery: Overview
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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01:22Drug Delivery: Miscellaneous Routes
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Transdermal patches transport drugs...
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01:18Drug Delivery: Enteral Route
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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01:29Drug Delivery: Parenteral Route
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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01:22Routes of Drug Administration: Overview
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Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
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Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
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