Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Microtubule Associated Proteins (MAPs)01:42

Microtubule Associated Proteins (MAPs)

4.3K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
4.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Prevalence of the Predisposing Gene MBD4 for Uveal Melanoma.

JAMA ophthalmology·2026
Same author

Modulation of striatal cAMP levels: A key pathway in the treatment of hyperkinetic movement disorders.

iScience·2026
Same author

Psychiatric Disorders and Apathy in Mixed Movement Disorders Linked to ADCY5 (MxMD-ADCY5).

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Genetic Background Predicts Uveal Melanoma Patients' Outcomes.

Ophthalmology science·2025
Same author

GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration.

Science advances·2025

相关实验视频

Updated: Jun 26, 2025

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

866

FMRP通过MAP1BB调节出生后的神经元迁移.

Salima Messaoudi1, Ada Allam1, Julie Stoufflet1,2

  • 1Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France.

eLife
|May 17, 2024
PubMed
概括

脆弱X综合征 (FXS) 由于缺少FMRP而损害神经元迁移. 恢复微管相关蛋白1B (MAP1B) 功能可以挽救这些发育缺陷.

关键词:
在FMRP中使用FMRP.在MAP1B中,您可以使用MAP1B.细胞骨架 细胞骨架脆弱的X信使核糖核蛋白.脆弱的X综合征 脆弱的X综合征微管相关蛋白 1B 微管相关蛋白这里是鼠标鼠标鼠标鼠标鼠标鼠标.神经元迁移的神经元迁移神经科学 神经科学

更多相关视频

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

10.2K
Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

10.0K

相关实验视频

Last Updated: Jun 26, 2025

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

866
Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

10.2K
Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

10.0K

科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 脆弱X综合征 (FXS) 是领先的遗传智力障碍,也是自闭症谱系障碍的主要遗传原因.
  • FXS是由脆弱的X信使核糖蛋白 (FMRP) 的缺乏引起的.
  • 在神经元迁移中FMRP的功能,这是一个关键的大脑发育过程,尚不清楚.

研究的目的:

  • 为了研究FMRP在神经元迁移中的作用,在大脑发育过程中.
  • 确定参与调节神经元迁移的FMRP目标.
  • 阐明FMRP影响神经元迁移的分子机制.

主要方法:

  • 在Fmr1-null小鼠中对产后面向迁移流 (RMS) 神经元的实时成像.
  • 通过RNA干扰诱导的Fmr1和MAP1B的淘汰.
  • 对神经元迁移,中枢体运动和微管细胞骨架结构的分析.

主要成果:

  • 缺少FMRP会导致Fmr1-null小鼠的神经元迁移延迟和轨迹改变.
  • 这些迁移性缺陷是细胞自主性的,并与中心体运动问题有关.
  • 微管相关蛋白1B (MAP1B) 被确定为一个关键的FMRP目标,它的淘汰拯救了迁徙缺陷.
  • 缺少FMRP会破坏核周围的微管,这是MAP1B敲击所救出的缺陷.

结论:

  • FMRP在编排神经元迁移方面发挥着至关重要的作用.
  • 在神经元迁移过程中,FMRP与MAP1B合作调节微管细胞骨架.
  • 这些发现揭示了FMRP在大脑发育和FXS病变发生过程中的新型神经发育功能.