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Updated: Jun 26, 2025

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
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人脑中的成人海马神经发生:更新,挑战和前景

Sophie Simard1, Natalie Matosin2, Naguib Mechawar1,3

  • 1McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Canada.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
|May 17, 2024
PubMed
概括

关于成年人海马神经发生的辩论仍在继续,来自免疫组织化学和下一代测序研究的结果相互矛盾. 本综述探讨了研究这一关键大脑过程的挑战和局限性.

关键词:
大人的海马神经发生是海马神经发生.有牙的吉鲁斯 (Gyrus)人类大脑 人类大脑免疫组织化学 免疫组织化学这是下一代测序.一个单细胞RNA测序.空间转录学 空间转录学

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Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis07:25

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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