增强抗瘤免疫力,使用具有刺激反应的半孔与化疗和光热疗法结合使用
Shuai Chen1, Rui Huang2,3, Feiyang Shen2,3
1Institute of Translational Medicine, National Facility for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Biomaterials science
|May 17, 2024
概括
这项研究引入了一种新的纳米粒子 (DOX/MSN-4S@PDA-HA),它结合化疗和光热疗法来激活抗瘤免疫力,并有效抑制瘤生长和转移.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 化疗因免疫抑制性瘤微环境 (TME) 和全身毒性而面临挑战.
- 光热疗法 (PTT) 可以通过释放瘤新抗原来激活抗瘤免疫力.
- 制定提高化疗疗效和减少副作用的策略至关重要.
研究的目的:
- 设计和评估一种用于联合化疗和光热疗法的新型纳米粒子系统.
- 研究纳米粒子激活抗瘤免疫力和克服TME的能力.
- 评估纳米粒子in vivo和in vitro的治疗疗效和有针对性的输送.
主要方法:
- 合成带有四素结合的半孔纳米颗粒 (MSN),载有多克索鲁比 (DOX) 并涂有多多巴胺 (PDA) 和酸 (HA).
- 评估药物释放动力学,H2S生成,酸/NIR触发性质和CD44向的输送.
- 评估体内和体外抗瘤疗效,包括TME调制,免疫细胞死亡 (ICD) 诱导和转移抑制.
主要成果:
- DOX/MSN-4S@PDA-HA纳米颗粒通过GSH敏感的四素化键和H2S生成证明了受控的DOX释放.
- 在NIR照射下,PDA涂层提供了酸敏感性和温和的光热特性.
- 实现了针对CD44表达瘤细胞的向输送,增强了药物积累并减少了全身毒性.
- 活体研究显示免疫抑制性TME的逆转,强烈的ICD诱导,显著的瘤生长抑制和抑制肺和肝转移.
结论:
- DOX/MSN-4S@PDA-HA纳米粒子提供了一个有前途的协同作用的化学光热疗法方法.
- 该系统有效地激活了抗瘤免疫力,并克服了免疫抑制的TME.
- 这种纳米颗粒配方表现出受控的药物释放,良好的生物相容性和显著的抗瘤能力,需要进一步研究癌症治疗.
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