结合型糖聚合物分散剂用于增强加工和储存稳定性
Claudia Giannachi1,2, Evin Allen2, Gráinne Egan2
1SSPC, the SFI Research Centre for Pharmaceuticals, School of Pharmacy, University College Cork, Cork T12 YT20, Ireland.
Molecular pharmaceutics
|May 17, 2024
概括
聚烯 (PVP) 和PVPVA增强了蛋白质疗法的无形糖的稳定性. 由于增加了结合,PVP比PVPVA更好地稳定了三糖再结晶.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 蛋白质疗法需要在干燥配方中进行稳定.
- 无形固态糖如糖和三糖是稳定性的关键辅助成分.
- 使用聚合物如聚乙烯 (PVP) 和聚乙烯酸乙烯 (PVPVA) 的聚化可提高无形糖的稳定性.
研究的目的:
- 为了研究聚合糖聚合物系统的稳定性.
- 评估聚合物类型和度对冷,干燥和潮湿状态下的糖稳定性的影响.
- 了解结和高透性在无形固态稳定中的作用.
主要方法:
- 糖糖或三糖与PVP或PVPVA在不同比率 (2:8到8:2) 的结合型化.
- 使用玻璃过渡温度 (Tg') 测量的冷溶液状态稳定性的分析.
- 使用动态蒸汽吸附 (DVS) 湿度提升实验评估干燥状态稳定性和水吸附效应.
主要成果:
- 冷糖-PVPVA溶液的Tg'比糖-PVP溶液的Tg'更高.
- 所有化系统都显示了类似的Tg值.
- 糖系统在暴露于湿度时表现出比三醇系统更大的无形稳定性.
- 添加PVP比PVPVA更有效地抑制了三糖再结晶,特别是在较低度下.
结论:
- 聚合物高度和键相互作用显著影响无形分散的固态稳定性.
- 与PVPVA相比,PVP与糖的结合更强,增强了无形稳定性并抑制了再结晶.
- 这些发现对于开发稳定生物制药固态配方至关重要.
相关概念视频
01:09Colloidal precipitates
565
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
565
03:22Colloids
17.4K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
17.4K
01:17Colloids and Suspensions
1.8K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
1.8K
01:20Types of Step-Growth Polymers: Polyesters
2.2K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
2.2K