雷米马佐拉姆对乳房外科手术的儿童出现痴呆症的影响:双盲随机试验
Yu-Hang Cai1, John Wei Zhong2, Hong-Yu Ma1
1Department of Anesthesiology and Perioperative Medicine, Second Affiliated Hospital and Yuying Children's Hospital, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, and Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.
雷米马佐拉姆有效地预防了在接受麻醉的儿童中出现的妄想. 连续输液和单次玻尿酸注射都显著降低了狂妄症的发生率和救援治疗的需要.
科学领域:
- 儿科麻醉 儿科麻醉
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 出现妄想是儿科麻醉中常见的问题,没有确立的预防方法.
- 这项研究旨在评估雷米马佐拉姆在预防儿科患者出现痴呆症方面的疗效.
研究的目的:
- 为了调查remimazolam作为连续输液或单剂量注射的假设,可以减少儿童出现狂妄症.
- 为了比较remimazolam组和对照组之间出现妄想的发生率和需要救援的需要.
主要方法:
- 120名儿童 (1-6岁) 被随机分为三个组:连续输注雷米马佐拉姆 (RC),单剂量玻尿酸雷米马佐拉姆 (RB) 和盐酸控制 (C).
- 主要结局是出现妄想的发生率,使用儿科麻醉出现妄想量表进行评估.
- 二次结果包括救援,恢复时间和不良事件.
主要成果:
- 雷米马佐拉姆显著降低了出现妄想的发生率:在RC中为5%,在RB中为7.7%,而在C中为35% (P < 0.003).
- 与对照组 (25%) (P < 0.014) 相比,在雷米马佐拉姆组 (5% RC,7.7% RB) 中需要救援的患者较少 (P < 0.014).
- 两组之间没有观察到恢复时间或不良事件的显著差异.
结论:
- 连续输液和单剂量玻尿酸雷米马佐拉姆都有效预防儿童出现妄想.
- 雷米马佐拉姆的使用提供了一种有希望的策略,通过减少出现妄想来改善儿科麻醉的结果.
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