抗衰老的化品:对安全性和有效性的系统审查
Megan Lau1, Jessica Mineroff Gollogly2,3, Jennifer Y Wang2
1New York University Grossman Long Island School of Medicine, Mineola, NY, USA.
Archives of dermatological research
|May 17, 2024
概括
这次审查发现,视网醇和维生素C是有效的抗衰老化品. 其他成分看起来很有希望,但需要更多的研究才能对皮肤的外观做出明确的建议.
科学领域:
- 皮肤病学和化品科学
- 基于证据的医学基于证据的医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 化品,混合化品和药品特性,越来越受欢迎,以改善皮肤的外观.
- 由于市场的增长,了解化品的安全性和有效性,特别是在抗衰老方面,至关重要.
- 需要进行系统审查,以巩固对抗衰老的化品成分的证据.
研究的目的:
- 系统地审查对抗衰老的化品的临床研究.
- 为各种化品成分的有效性和安全性提供基于证据的建议.
- 引导消费者和医生选择有效的抗衰老化品.
主要方法:
- 系统地搜索PubMed,Embase和Cochrane数据库的文献,直到2023年1月1日,遵守PRISMA指南.
- 包括32项研究 (20项RCT,12项非随机) 涉及1236名患者,评估了维生素C,雷丁醇,巴库基醇和生长因子等成分.
- 使用牛津证据医学中心指导方针对证据的强度进行评分,以告知临床建议.
主要成果:
- 雷丁醇和维生素C有强有力的证据 (A级) 证明其抗衰老功效.
- 甲基雌二醇酸,巴库基醇,四亚斯酸和生长因子获得C级推.
- 大多数被审查的化品表现出良好的安全性,副作用最小;一些成分缺乏足够的证据.
结论:
- 雷丁醇和维生素C是根据目前的证据推的抗衰老化品.
- 对于其他化品成分,需要进行进一步的研究,包括长期研究和更多的随机对照试验.
- 该审查为有关在抗衰老疗法中使用化品的知情决策提供了基础.
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