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阿尔法阻塞剂是否可以降低经过经前列腺活检后尿的风险? 一个系统的叙事审查
Zein Alhamdani1, Samuel Poppenbeek2, Damien Bolton3
1Department of Urology, University of Melbourne, Austin Health, 145 Studley Rd, Heidelberg VIC, Melbourne, 3084, Australia. zeinfiras@hotmail.com.
World journal of urology
|May 17, 2024
概括
阿尔法阻塞剂在经前列腺活检 (TPB) 后预防急性尿时可能有轻微的益处. 然而,需要更多的研究,特别是随机对照试验,以确认有效性和建立协议.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 超前列腺活检 (TPB) 优先于通过直肠超声导向前列腺活检 (TRUSB),因为感染并发症的发生率较低.
- 急性尿 (AUR) 是TPB之后的主要并发症.
- 在TPB中用于AUR预防的α-阻断剂的使用是从有限的TRUSB数据中推断出来的.
研究的目的:
- 审查有关阿尔法阻断剂在预防TPB后AUR有效性的现有证据.
- 评估TPB协议中使用α阻断剂的现有证据基础.
主要方法:
- 使用关键词"跨关节"和"保留"对奥维德·梅德林和埃姆巴斯进行系统的文献搜索.
- 纳入和排除标准用于确定比较α阻断剂使用与不使用用于TPB中AUR预防的研究.
- 对361个记录进行了选,结果包括了5项研究.
主要成果:
- 没有确定随机对照试验 (RCT);证据是基于观察性研究.
- 一项观察性研究表明,使用tamsulosin,AUR从12.5%降低到5.3%.
- 其他观察性研究的结果相互矛盾,指出了潜在的危害,但归因于研究的局限性.
结论:
- 根据目前有限的证据,外科阿尔法阻断剂在预防TPB后的AUR方面可能提供微弱的益处.
- 存在着对高质量的RCT的重大需求,以建立基于证据的协议,用于TPB中的α阻断剂使用.
- 目前的文献缺乏在TPB中使用α阻断剂的标准协议.
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