在拉玛中摄入Astragalus spp引起的 lysosomal储存疾病:一个新出现的关注
Raúl E Marin1, Francisco A Uzal2
1Facultad de Ciencias Agrarias, Universidad Nacional de Jujuy, Jujuy, Argentina.
Veterinary research communications
|May 17, 2024
概括
含有斯瓦因素的有毒植物会导致溶酶体储存疾病. 阿斯特拉加勒斯物种诱导了拉玛的神经疾病,形和死亡率,通过临床症状和斯瓦因素检测来诊断.
科学领域:
- 兽医毒理学 兽医毒理学
- 细胞病理学细胞病理学
背景情况:
- 溶解体储存疾病是由功能障碍的溶解体引起的,导致基质积累和细胞死亡.
- 获得的形式往往是由植物衍生的化物如斯瓦因素引起的,这些化物抑制了关键的lysosomal和Golgi酶.
- 斯旺森因与各种植物属的神经系统疾病有关.
研究的目的:
- 研究阿斯特拉加勒斯物种,特别是阿斯特拉加勒斯 garbancillo 和阿斯特拉加勒斯 punae,对的毒性影响.
- 为了确定动物中Astragalus诱导的中毒的致病原体和诊断方法.
主要方法:
- 临床观察受影响的喇嘛.
- 组织的显微镜和超结构检查.
- 莱克的组织化学.
- 在植物样本中量化swainsonine.
- 评估放牧区的植物存在情况.
主要成果:
- 两种阿斯特拉加勒斯 (Astragalus) 种被确定为导致玛的神经疾病的原因.
- 阿斯特拉加卢斯 (Astragalus garbancillo) 也与后代的发育不良,堕胎和新生儿死亡率有关.
- 诊断依赖于临床症状,病理发现和斯瓦辛素确认.
结论:
- 阿斯特拉加卢斯物种是斯瓦因素的重要来源,对驼类动物构成风险.
- 全面的诊断方法对于识别和管理阿斯特拉加卢斯中毒是必不可少的.
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