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评估纳米体与SARS-CoV-2 Nsp9的相互作用

Gennaro Esposito1,2, Yamanappa Hunashal1, Mathias Percipalle1

  • 1Division of Science, New York University Abu Dhabi, Abu Dhabi, UAE.

PloS one
|May 17, 2024
PubMed
概括

研究人员使用NMR光谱学研究SARS-CoV-2 Nsp9蛋白与纳米体2NSP90.0.的相互作用. 这种相互作用是潜在的抗病毒标,因为NSP9对冠状病毒的病毒复制至关重要.

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Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...