TREM2 缺乏重新编程肠道巨细胞和微生物群,以增强抗PD-1 瘤免疫疗法

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Updated: Jun 26, 2025

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
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Published on: May 21, 2012

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Blanda Di Luccia1,2, Martina Molgora1, Darya Khantakova1

  • 1Department of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.

Science immunology
|May 17, 2024
PubMed
概括

缺乏巨细胞受体TREM2的小鼠表现出增强的抗PD-1瘤消除. 这与肠道细菌Ruminococcus gnavus有关,这表明它可能是一种益生菌,可以提高抗PD-1疗法的有效性.

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