白物质在生命周期中的轨迹
Stefania Conte1, Dabriel Zimmerman2, John E Richards3
1Department of Psychology, State University of New York at Binghamton, Vestal, NY, United States of America.
PloS one
|May 17, 2024
概括
白质体积和微观结构性质在整个生命周期中发生非线性变化. 这些发育轨迹因年龄,性别,半球和特定的白质度量而异.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 放射学 放射学是一门学科.
背景情况:
- 白物质 (WM) 在人类发展和衰老过程中经历了重大变化.
- 了解这些与年龄相关的WM变化对于诊断神经系统疾病和评估大脑健康至关重要.
研究的目的:
- 在整个生命周期中调查白质 (WM) 宏观和微观结构性质的与年龄相关的变化.
- 用各种数学函数建模这些变化的轨迹.
- 探索生物性别和半球差异对WM发展的影响.
主要方法:
- 从2周到100岁的个体收集了10879个结构性和6186个扩散权重的MRI扫描.
- 分析了全脑和通道特定的WM部分体积和微观结构特性 (FA,MD).
- 配备线性,方位,立方体和指数模型来描述与年龄相关的WM变化.
主要成果:
- 在婴儿/童年时,WM体积急剧增加,然后在成年时减缓,随着年龄的增长而下降.
- 微结构性质,如分数异构性 (FA) 和平均扩散性 (MD),在整个生命周期中表现出独立的非线性轨迹.
- 与年龄相关的WM变化,包括FA增加和MD减少,显示性别和半球调制,特别是在关联通道.
结论:
- 白质的宏观和微观结构变化在整个生命中遵循非线性,年龄依赖的轨迹.
- 指数式变化是体积,FA和MD的早期生命WM发展 (前五年) 的特征.
- 这种寿命方法为动态WM变化及其影响因素提供了新的见解.
相关概念视频
Spinal Cord: Cross-sectional Anatomy
1.8K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
1.8K
Cognitive Development During Adulthood
94
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
94
Nervous Tissue: Myelin
2.6K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
2.6K
Neuroplasticity
329
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
329
Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K


