一项关于渐进性肺纤维化患病率和预后的研究:一项追溯观察性研究
Ji Hoon Jang1, Eun Jun Choe1, So Young Jung2
1Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Medicine
|May 17, 2024
概括
渐进性肺纤维化 (PPF) 影响40%的非异形性肺纤维化患者. 风险因素包括类固醇/免疫抑制剂使用和家庭氧气,PPF与较高的死亡率有关.
科学领域:
- 肺部病理学 肺部病理学
- 呼吸系统医学 呼吸系统医学
- 临床研究 临床研究
背景情况:
- 间歇性肺病 (ILD) 是一组复杂的200多个肺部疾病.
- 疾病进展是ILD的关键预后因素.
- 渐进性肺纤维化 (PPF) 是一个最近定义的临床实体.
研究的目的:
- 为了确定非异形性肺纤维化 (IPF) 患者中PPF的患病率.
- 识别与PPF开发相关的风险因素.
- 评估PPF患者的预后和死亡风险.
主要方法:
- 从2010年1月到2023年6月对215名非IPF患者的回顾性分析.
- 用标准定义的PPF包括呼吸系统症状恶化,生理和放射性进展.
- 用多变量逻辑回归和考克斯比例危险模型进行分析.
主要成果:
- 在研究的非IPF患者中,PPF的患病率为40%.
- 与结合组织疾病相关的ILD是最常见的类型 (52.3%).
- 类固醇/免疫抑制剂使用 (OR:2.57) 和家庭氧气使用 (OR:25.17) 是PPF的独立风险因素.
- 在PPF组中,死亡率明显高于PPF组 (24.4%对2.3%).
- 疾病进展,年龄较大和强迫生命能力较低是独立的死亡风险因素.
结论:
- 在现实实践中,非IPF患者中有40%患有PPF.
- 联合类固醇和免疫抑制疗法以及家庭使用氧气是PPF的重要风险因素.
- PPF与死亡率大幅增加有关,疾病进展,年龄和FVC作为关键预测因素.
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