相关实验视频

Updated: Jun 26, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

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SF3B1的E592K变体产生了独特的RNA错误拼接,并与高风险的MDS无环 sideroblasts相关

In Young Choi1, Jonathan P Ling2,3,4, Jian Zhang5

  • 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

Blood advances
|May 17, 2024
PubMed
概括

在骨髓分裂综合征 (MDS) 中,SF3B1 E592K突变与高风险疾病和低生存率有关,与其他SF3B1突变不同. 这种特定的突变改变了RNA拼接和疾病特征,影响了MDS的预后.

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RNA Splicing01:32

RNA Splicing

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Alternative RNA Splicing

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Lesson: Translation
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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