高血压患者的抗高血压药物和痴呆风险:一项基于全国人口的全国性研究
Chih-Ying Lin1, Pei-Hsien Chen2, Chiu-Lin Tsai3
1Department of Chinese Traumatology Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
概括
高血压显著增加了痴呆症的风险. 发现抗高血压药物 (AHM) 和传统中医药 (TCM) 可以降低高血压患者的痴呆发病率,这表明潜在的保护作用.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 老年学是指老年学的学科.
背景情况:
- 高血压是一种普遍的疾病,疑似与认知能力下降有关.
- 关于高血压对痴呆风险和治疗的作用的直接影响的证据有限.
研究的目的:
- 研究高血压与患痴呆症的风险之间的关联.
- 为了确定抗高血压药物 (AHM) 和传统中医药 (TCM) 是否能降低高血压患者痴呆的发病率.
主要方法:
- 使用台湾国家医疗保险研究数据库 (2000-2016) 进行回顾性队列研究和病例控制研究.
- 分析包括587,762名匹配的参与者,以评估高血压与非高血压组中的痴呆风险.
- 研究了特定的AHM (ARB,CCB,利尿剂) 和TCM对痴呆发病率的影响.
主要成果:
- 高血压与所有原因痴呆症,阿尔茨海默病和血管痴呆症的风险明显增加有关 (aHR, 2.86).
- ангиотензинII受体阻断剂 (aHR,0.55),通道阻断剂 (aHR,0.76) 和利尿剂 (aHR,0.93) 显著降低了痴呆症的发生率.
- 传统中医药的使用也与高血压患者新诊断的痴呆症发病率较低有关 (aHR,0.90).
结论:
- 高血压是痴呆症的一个重要风险因素.
- 抗高血压药物,特别是ARB,CCB和利尿药,显示出对痴呆的保护作用.
- 传统中医也可能在降低高血压患者痴呆症发病率方面发挥作用.
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