血清中介质素-41的增加与肌痛严重症的疾病严重程度相关
Zhouyi Wang1, Zhouao Zhang1, Tiancheng Luo1
1Department of Neurology, Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Quanshan District, Xuzhou, Jiangsu, China; Central Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
International immunopharmacology
|May 17, 2024
概括
干白素-41 (IL-41) 在肌痛性骨髓灰质炎 (MG) 患者中升高,与疾病严重程度相关. 这项研究表明,IL-41可能在MG病变发生过程中发挥作用,并可以作为诊断生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 自免疫性疾病 自免疫性疾病
- 神经学 神经学
背景情况:
- 骨髓灰质炎 (MG) 是一种自身免疫性疾病,由于激活的B细胞的病原性抗体影响了神经肌肉结.
- 介素-41 (IL-41) 是一种新型免疫调节性细胞因子,与各种炎症和自身免疫性疾病有关.
- IL-41在MG病变发生中的特定作用在很大程度上仍未被探索.
研究的目的:
- 在患有骨髓灰质炎的患者中检查IL-41的血清水平.
- 确定IL-41水平与MG严重程度的临床指标之间的相关性.
- 评估IL-41作为MG生物标志物的诊断潜力.
主要方法:
- 酶相关免疫吸收试验 (ELISA) 用于量化60名MG患者和30名健康对照 (HC) 的血清IL-41水平.
- 流细胞计分析了T细胞,B细胞和自然杀手细胞子集.
- 评估了与临床参数 (例如,MGFA分类,MG-ADL) 和炎症标志物 (例如,hs-CRP,PLR) 的相关性,以及用于诊断价值的ROC分析.
主要成果:
- 血清IL-41水平在MG患者中明显高于HC患者,在更严重的MGFA等级 (III+IV) 与较轻度等级 (I+II) 之间.
- IL-41与MG-ADL,MGFA分类,PLR和CD19+B细胞比例正相关,但与hs-CRP和循环血细胞负相关.
- 随着efgartigimod治疗,IL-41水平暂时增加,但随着临床改善而下降,ROC分析表明MG的诊断价值.
结论:
- 血清IL-41的升高与肌痛性骨髓灰质炎和疾病严重程度有关.
- IL-41可能是MG免疫病理学的组成部分.
- IL-41显示出作为一种潜在的诊断生物标志物来治疗肌痛性骨髓灰质炎.
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