新生儿神经行为与非常早产婴儿从2岁到3岁的发育变化相关
Alexandrea L Craft1, Marie Camerota1, Cynthia Loncar2
1Women and Infants Hospital, Providence, RI, United States of America; Warren Alpert Medical School of Brown University, Providence, RI, United States of America.
Early human development
|May 17, 2024
概括
在NICU出院时,高风险婴儿的神经行为评估可以预测以后的发育挑战. NICU网络神经行为量表 (NNNS) 资料识别了极早产婴儿面临认知和语言衰退的风险.
科学领域:
- 新生儿发育的新生儿发展
- 神经行为评估是神经行为评估.
- 高风险的婴儿结果.
背景情况:
- 非常早产的婴儿 (<30周怀孕) 面临着重大的发育风险.
- 早期的神经行为评估对于识别有风险的婴儿至关重要.
- 对早产婴儿的长度发展跟踪对于干预计划至关重要.
研究的目的:
- 调查NICU网络神经行为尺度 (NNNS) 资料和发育轨迹之间的关联.
- 确定NNNS在NICU出院的概况是否预测2至3岁之间的认知和语言结果的变化.
- 了解新生儿神经行为对非常早产婴儿的长期发育影响.
主要方法:
- 对433名非常早产婴儿进行的前性多站点研究 (非常早产婴儿新生儿结果 - NOVI队列).
- 在NICU出院时使用NNNS配置文件评估新生儿神经行为.
- 在2岁和3岁时使用贝利婴幼儿发育尺度 (BSID-III) 评估认知和语言发展.
- 用于分析NNNS配置文件和BSID-III得分变化之间的关联的概括估计方程.
主要成果:
- 患有失调NNNS特征的婴儿在2至3岁时,认知 (OR=2.66) 和语言 (OR=2.53) 评分下降的可能性增加.
- 相反,具有良好调节的NNNS配置文件的婴儿与失调配置文件的婴儿相比,更有可能显示认知得分增加 (OR=2.03).
- 研究样本出生时的妊娠年龄平均为27周.
结论:
- 在NICU出院之前获得的NNNS概况有效地识别了风险更高的非常早产婴儿以后的语言和认知困难.
- 新生儿神经行为评估为评估非常早产婴儿提供了一个临床上重要的工具.
- 这些发现支持使用NNNS来为脆弱的早产婴儿提供有针对性的治疗和干预计划.
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