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运动可以增强肝脏线粒体的结构和功能,同时防止内细胞网膜应激和与代谢功能障碍相关的脂肪性肝病,在食高脂肪饮食的小鼠中
Henrique Souza-Tavares1, Daiana Araujo Santana-Oliveira1, Isabela Macedo Lopes Vasques-Monteiro1
1Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology. Rio de Janeiro State University, Rio de Janeiro, Brazil.
Nutrition research (New York, N.Y.)
|May 17, 2024
概括
高强度间歇训练 (HIIT) 通过改善胰岛素敏感性,减少内分泌网膜 (ER) 应激,并促进高脂肪饮食小鼠的β-氧化,防止与代谢功能障碍相关的脂肪性肝病 (MASLD).
科学领域:
- 代谢性疾病是代谢性疾病.
- 运动生理学 运动生理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个越来越令人担忧的疾病,其无声的进展和有限的治疗方法.
- 葡萄糖脂毒性驱动MASLD通过诱导内分泌网膜 (ER) 压力,减少β-氧化,并增加脂质生成.
- 众所周知,体育炼通过维持ER和线粒体功能来保护MASLD.
研究的目的:
- 调查高强度间歇训练 (HIIT) 是否可以预防高脂肪 (HF) 饮食养小鼠的MASLD发展.
- 评估HIIT对胰岛素敏感性,ER压力和肝脏β氧化的影响.
主要方法:
- 40只雄性C57BL/6J小鼠被分为四组:控制饮食,控制饮食+HIIT,高频饮食和高频饮食+HIIT.
- 小鼠接受了为期10周的协议,包括控制或高压饮食,每周进行三次HIIT训练.
- 分析了主要的代谢,ER压力,线粒体和脂质性标记物.
主要成果:
- 在HF饮食中的小鼠中,HIIT可以防止体重增加,并保持胰岛素敏感性.
- 在HF-HIIT组中,HIIT减轻了ER压力,保留了线粒体超结构,并增强了肝脏β-氧化.
- 增加素和素-1/PGC-1α的表达表明线粒体生物发生的增强和抗菌作用.
结论:
- 在小鼠模型中,HIIT有效地防止了MASLD的发展,即使和脂肪酸摄入量高.
- 定期的HIIT练习可以改善胰岛素敏感性,减少ER压力,增强肝脏β氧化,提供潜在的治疗策略.
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