周周体内的全孕:相关物质,度和挑战 - - 一个系统的审查
Maria Katharina Grötsch1, Ulrike Ehlert1
1Clinical Psychology and Psychotherapy, University of Zurich, Switzerland; Clinical Psychology and Psychotherapy, Binzmühlestrasse 14, Zurich 8050, Switzerland.
Psychoneuroendocrinology
|May 17, 2024
概括
在周产期内,全孕原 (ALLO) 含量会波动,测量方法会对结果产生重大影响. 标准化对于可靠的女性ALLO研究至关重要.
科学领域:
- 神经内分泌学神经内分泌学
- 围产期心理健康问题
背景情况:
- 孕激素代谢物和神经类固醇的阿洛普雷格纳诺 (ALLO) 调节GABA受体,表现出抗抑郁和抗焦虑的特性.
- 经批准用于产后抑郁症治疗,ALLO在产前期的作用需要澄清,因为研究结果不一致.
- 现有的研究缺乏对ALLO相关物,度和围产期妇女的测量挑战的系统审查.
研究的目的:
- 系统地审查对象,度和测量挑战,在周围产妇妇女.
- 综合现有的关于ALLO在围产期内生物和情绪相关的文献.
- 确定影响ALLO测量可靠性的因素.
主要方法:
- 在PubMed和PsycINFO数据库的系统文献搜索于2023年8月进行.
- 包括测量围产妇女ALLO度的原始研究文章.
- 不包括非原始研究,非人类受试者,干预,方法验证和重复队列.
主要成果:
- 十九篇文章 (N=1401) 符合纳入标准;七篇专注于生物相关性,12篇专注于情绪相关性.
- 情绪相关性显示出混合的结果:六项研究没有发现任何关联,四项研究发现负相关性,两项研究发现正相关性.
- 在怀孕期间,ALLO水平增加,分娩后降低,并在六个月内保持低水平;在血中,气色谱-质谱 (GC-MS) 是常见的;观察到显著的矩阵和方法效应.
结论:
- 测量方法 (例如,RIA与其他) 和矩阵 (血清与血) 显著影响ALLO量化.
- 矩阵和方法效应,以及测量时间和研究设计,影响ALLO可靠性.
- 对ALLO测量的标准化对于准确解释周围产妇期荷尔蒙和情绪相关的测量至关重要.
关键词:
孕诺 (Allopregnanolone) 是一种含有甲基的药物.对于GABA来说,这是一个很好的选择.产妇 母亲 产妇 母亲 产妇这是一种神经类固醇.周围部分 (peripartum) 是一个周围部分.怀孕 怀孕 怀孕 怀孕生殖情绪障碍 生殖情绪障碍更多相关视频
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