细颗粒和粗颗粒对特定原因的脑血管死亡率的影响的区别:个体级别的案例交叉研究
Yifeng Qian1, Xiaozhen Su2, Huiting Yu3
1Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, China.
Ecotoxicology and environmental safety
|May 17, 2024
概括
短期接触细颗粒物 (PM2.5) 和粗颗粒物 (PM2.5-10) 会增加脑血管疾病的死亡率. 缺血性中风和中风后果的风险特别高,对女性和老年人影响更大.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 心血管研究研究心血管研究
背景情况:
- 短期暴露于细颗粒物 (PM2.5) 和粗颗粒物 (PM2.5-10) 与增加脑血管疾病风险有关.
- 对于PM2.5和PM2.5-10对特定类型的脑血管疾病的影响的差异性了解有限.
研究的目的:
- 调查短期暴露于PM2.5和PM2.5-10与脑血管疾病死亡率之间的关联.
- 探索PM2.5和PM2.5-10对各种脑血管疾病亚型的潜在差异性影响.
主要方法:
- 利用来自中国上海 (2005-2021) 的个人脑血管死亡记录.
- 使用个人级别,时间分层,案例交叉设计与分布式滞后模型 (最大滞后7天).
- 分析了使用条件后勤回归的关联,探索按性别,年龄和季节的效果修改.
主要成果:
- 总共分析了388,823例脑血管疾病死亡.
- PM2.5的10μg/m3增加与所有脑血管疾病 (1.35%),缺血性中风 (1.84%) 和中风后续 (1.53%) 的死亡率增加有关.
- 对于PM2.5-10,观察到类似的增加,女性,80岁以上的个体和温暖的季节中更大的关联.
结论:
- 短期暴露在PM2.5和PM2.5-10中独立地增加了脑血管疾病死亡风险.
- 缺血性中风和中风后果似乎特别容易受到颗粒物暴露的影响.
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