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Updated: Jun 26, 2025

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过渡性氧胆固醇治疗抑制TCR信号传递,促进长期免疫力

Zhengxu Ren1, Kun Wang2, Yong Zhang3

  • 1Key Laboratory of Multi-Cell Systems, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

Cell chemical biology
|May 17, 2024
PubMed
概括

研究人员发现7-α-胆固醇 (7a-HC) 是一种抑制T细胞受体 (TCR) 信号传递的化学工具. 这一发现在TCR-T细胞治疗中增强了长期抗瘤功能.

关键词:
7-α-基胆固醇是7α-基胆固醇的一种.CD3 膜结合方式T细胞受体受体的 T 细胞受体.这是一种TCR-T细胞疗法.膜的物理化学特性 膜的物理化学特性

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