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为癌症治疗调节肠道微生物组的新策略

Young Seok Cho¹, Kai Han², Jin Xu¹

¹Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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概括

益生菌,益生菌和后生菌通过调节肠道微生物群,在癌症治疗中表现有前途. 目前正在制定工程策略,以改善这些疗法的交付并减少这些疗法的副作用.

科学领域:

微生物学微生物学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

基因组学,转录组学和代谢学已经加深了对肠道微生物组在抗癌疗法的有效性和毒性的作用的理解.
益生菌,益生菌和后生菌是调节肠道微生物群,肠道屏障功能和免疫反应的关键,为癌症治疗提供了新的途径.

研究的目的:

审查益生菌,益生菌和后生菌对肠道微生物群的影响及其在癌症治疗中的有效性.
总结创新的工程策略,以克服口服抗癌药物输送方面的挑战.
探索工程微生物组调节方法在减轻化疗和免疫疗法的副作用方面的潜力.

主要方法:

关于微生物组研究和癌症治疗的最新进展的文献综述.
在癌症中分析益生菌,益生菌和后生菌的作用机制.
检查工程策略,以提高药物输送和生物可用性.

主要成果:

益生菌,益生菌和后生菌通过影响肠道微生物群,显示出作为癌症治疗方式的潜力.
工程方法对于克服胃肠道障碍和改善基于微生物组的治疗方法的口服药物输送至关重要.
工程微生物组调制可能有助于减轻与免疫疗法和化疗相关的不良影响.

结论:

由益生菌,益生菌和后生菌调节的肠道微生物组,在癌症治疗中提供了一个有希望的前沿.
通过创新的工程来克服交付和生物可用性挑战对于临床翻译至关重要.
有针对性的微生物组干预措施有可能改善患者的治疗结果,并减少与治疗相关的毒性.

关键词:

癌症治疗治疗癌症治疗我们的肠道微生物群.免疫治疗是一种免疫疗法.纳米医学是一种纳米医学.后生物学的后生物学.益生菌益生菌益生菌益生菌益生菌益生菌

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