一种经过修改的库什纳 - 摩尔方法来描述小规模器性能对平板电脑压缩的影响
Hikaru G Jolliffe1, Martin Prostredny1, Carlota Mendez Torrecillas1
1CMAC, Technology and Innovation Centre, 99 George Street, Glasgow G1 1RD, UK.
International journal of pharmaceutics
|May 17, 2024
概括
这项研究揭示了Froude数量化的混合强度是新型迷你混合机滑动态的关键,与传统混合机不同,在传统混合机中,填充水位至关重要. 这一发现有助于更好地理解固体剂型的粉末加工.
科学领域:
- 制药技术 制药技术 制药技术
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
背景情况:
- 连续直接压缩 (CDC) 在固体剂量形式的生产中提供了减少的材料,时间和能量.
- 了解粉末机性能对CDC至关重要,但现有的研究重点是低强度批量操作.
- 传统的批量混合机在低弗劳德数 (Fr < 0.4) 时工作,这限制了它们的混合强度和适用于CDC的应用.
研究的目的:
- 为了研究新型迷你混合器的性能,使用不同的操作模式 (静态容器,旋转刀片).
- 为了比较迷你机的滑动态和对平板电脑质量属性的影响,与传统的机进行比较.
- 评估混合强度 (弗劳德数) 和操作参数对CDC粉末混合的影响.
主要方法:
- 使用了一个带有静态容器和旋转轴的微型混合机.
- 在迷你混合机更广泛的操作范围 (包括 Fr > 1) 内的各种混合强度和调节.
- 分析了平板电脑压缩数据,并通过结合Froude数来修改现有的滑模型.
主要成果:
- 来自迷你混合器的平板电脑压缩数据在不同的混合强度上遵循了一个共同的轨迹.
- 修改后的模型方程准确地预测了高弗劳德数 (Fr > 1) 的结果.
- 混合强度 (弗劳德数) 和转速对于滑动态至关重要,而在迷你混合机中,填充水平不那么重要.
结论:
- 迷你混合器的设计允许更高的混合强度,这对于CDC的高效滑至关重要.
- 由弗罗德数表示的混合强度是预测这种新混合器系统中的滑动态的关键参数.
- 该方法在不同配方中证明了有效性,突出了其优化CDC流程的潜力.
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