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Updated: Jun 26, 2025

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
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高特异性阿胺陷用于极端友性RNA聚合酶

Ivan Petushkov1, Andrey Feklistov2, Andrey Kulbachinskiy1

  • 1National Research Center "Kurchatov Institute", Moscow, 123182, Kurchatov Sq. 2, Russia; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.

Biochimie
|May 17, 2024
PubMed
概括

研究人员开发了一种合成DNA吸收体,该吸收体具有高亲和力,可以与细菌RNA聚合酶 (RNAP) 结合. 这种胺体通过阻断DNA相互作用来抑制RNAP活性,为结构研究和药物查提供了潜力.

关键词:
亚普特美尔 (Aptamer) 是一种药物.德伊诺科克-热马斯菌极端友好的细菌是一种极端友好的细菌.这种RNA聚合酶是RNA聚合酶.转录抑制剂转录抑制剂

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Eukaryotic RNA Polymerases00:58

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RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
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