尿道支架:你的眼睛看不到的东西! 一个体外试验研究研究
Stessy Kutchukian1, Marie Chicaud2, Mariela Corrales3
1GRC n(o) 20, groupe de recherche clinique sur la lithiase urinaire, hôpital Tenon, Sorbonne université, 75020 Paris, France; Service d'urologie, hôpital Tenon, Assistance publique-Hôpitaux de Paris, Sorbonne université, 4, rue de la Chine, 75020 Paris, France; PIMM, UMR 8006 CNRS-Arts et métiers ParisTech, 151, boulevard de l'Hôpital, 75013 Paris, France; Service d'urologie, CHU de Poitiers, Poitiers, France.
The French journal of urology
|May 17, 2024
概括
所有尿道支架 (STENTS) 在使用前都会出现表面缺陷,无论材料或设计如何. 这些不规则可能会导致支架和并发症.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物材料科学 生物材料科学
- 医疗设备工程 医疗设备工程
背景情况:
- 尿道支架 (STENTS) 对于尿道排水至关重要.
- 支架的表面特性可以影响临床结果,包括和感染.
- 使用前表面表征对于了解支架性能至关重要.
研究的目的:
- 进行各种未使用的尿路支架模型表面的体外表征和比较.
- 识别和量化不同支架类型和组件的表面缺陷.
主要方法:
- 在体外分析6个未使用的尿路支架模型 (聚氨和).
- 高分辨率扫描电子显微镜 (HR-SEM) 用于检查四个支架部分:表面核心,侧孔,尿道环和黑色标记表面.
- 分析重点是识别大于10μm的缺陷,每种支架模型有三个样本.
主要成果:
- 所有分析的尿道支架 (STENTS) 都显示了表面缺陷,无论其组成或形状如何.
- 缺陷主要在支架环和侧孔上发现.
- 标记表面在一些模型中显示出缺陷,其中一个模型表现出优越的光滑性.
- 在所有STENTS的横截面区域中也发现了不规则.
结论:
- 在临床使用之前,没有尿路支架 (STENT) 是完全光滑的.
- 预先存在的表面不完美可能在支架层中起作用,可能与感染和尿液成分相关.
- 制造工艺和材料特性都可能影响尿路支架的外表面光滑度.
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