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在微生物中共同利用碳来源,用于化学品的生物生产

Qian Ma¹, Jinhang Yi², Yulin Tang²

¹Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China; National and Local United Engineering Lab of Metabolic Control Fermentation Technology, Tianjin University of Science and Technology, Tianjin 300457, China.

Biotechnology advances

|May 17, 2024

概括

同时利用多个碳来源可以增强微生物对化学品的生产. 克服碳催化剂抑制 (CCR) 的策略可以提高微生物细胞工厂的效率.

科学领域:

生物技术是生物技术.
代谢工程是代谢工程.
微生物学微生物学

背景情况:

微生物细胞工厂依赖碳来源进行生长和代谢,影响产品合成.
多个碳来源的共同利用提供了更高的效率,但受到碳催化剂抑制 (CCR) 的阻碍.

研究的目的:

审查CCR机制和战略,以有效地共同利用碳来源.
通过共同利用策略突出微生物生物生产的进步.

主要方法:

总结碳催化剂抑制 (CCR) 的机制.
共同利用的详细策略:CCR减缓,二次碳源工程,强迫性共同利用,共同文化方法和进化方法.

主要成果:

联合利用策略显著提高了生物生产效率 (量,产量,生产率).
代表性研究表明,通过共同利用,化学生物合成的实质性增长.

结论:

克服CCR和优化碳源吸收是有效生物生产的关键.
结合代谢工程和进化方法,通过共同利用来增强化学生物合成.

关键词:

碳催化剂抑制抑制碳催化剂的抑制.共同文化是一种共文化.共同利用是一种共用.进化进化进化进化进化进化进化混合碳来源混合碳来源

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