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与喉炎和喉携带相关的Streptococcus pyogenes emm型的全球流行病学比较

Gabrielle de Crombrugghe¹, Anne Botteaux², Joshua Osowicki³

¹Molecular Bacteriology Laboratory, European Plotkin Institute for Vaccinology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium; Department of Paediatrics, Brussels University Hospital, Academic Children Hospital Queen Fabiola, Université Libre de Bruxelles, Brussels, Belgium.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

|May 17, 2024

概括

造成喉炎的Streptococcus pyogenes菌株与无症状传播的不同. 运输菌株显示出更大的多样性,并与特定的emm集群联系在一起,特别是在人类发展指数较低的环境中.

科学领域:

微生物学微生物学
流行病学流行病学
公共卫生公共卫生

背景情况:

杆菌 pyogenes 是一个重要的人类病原体.
emm型决定M蛋白,影响S. pyogenes的毒性和宿主相互作用.
普遍存在的教条表明,类似的emm类型会导致喉炎和无症状运输.

研究的目的:

通过比较S. pyogenes emm-types从喉炎和全球运输来挑战这个教条.
分析与人类发展指数 (HDI) 相关的菌株分布和多样性.

主要方法:

全球S. pyogenes emm-type和emm-cluster数据 (1990-2023) 的系统审查.
对Emm类型分布的比较以及喉炎和运输隔离物之间的多样性.
在当地HDI值的背景下进行分析.

主要成果:

分析了来自34个国家的71项研究的20222个分离物.
运输菌株表现出较高的emm型多样性 (28.9) 比喉炎菌株 (11.4).
运输emm-类型不成比例地来自emm-集群E和D ("通用"或"皮肤"菌株).

结论:

这项研究挑战了关于S. pyogenes emm-types在炎和运输中的普遍教条.
了解S. pyogenes携带流行病学至关重要,特别是在低和中等HDI国家.
对携带菌株的更好了解有助于破译疫苗效应.

关键词:

一组A型链球菌人类发展指数 (HDI)耳鼻炎是一种耳鼻炎.菌株多样性菌株多样性组织热带主义组织热带主义

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