所有我们需要知道的关于脂蛋白 (a)
Courtney Bess1, Anurag Mehta2, Parag H Joshi1
1Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern, Dallas, TX, United States of America; Parkland Health and Hospital System, Dallas, TX, United States of America.
Progress in cardiovascular diseases
|May 17, 2024
概括
脂蛋白 (Lp) 是心血管疾病的关键遗传风险因素. 建议所有成年人进行Lp (a) 检测,以指导个性化预防策略和新兴疗法.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 预防医学 预防医学
背景情况:
- 脂蛋白 (Lp) 是一种由基因决定的宏分子复合体.
- Lp(a) 独立且因果相关于动脉样硬化心血管疾病 (ASCVD) 和动脉狭窄症.
- 拟议的机制包括促炎性,前血栓性和前动脉性通路.
研究的目的:
- 要突出脂蛋白在心血管风险评估中的意义.
- 讨论Lp(a) 测试的不断变化的格局及其对ASCVD预防的影响.
- 审查新兴的针对性治疗方法,以减少Lp.
主要方法:
- 审查当前的指导方针和新兴的临床研究.
- 分析Lp(a) 在初级和二级ASCVD预防中的作用.
- 讨论风险分层工具和治疗干预措施.
主要成果:
- 测量标准化正在改善,有指导方针支持 ASCVD 风险预测的终身测试.
- 新兴的Lp (a) 降低疗法正在进行临床研究,以确定其对心血管的益处.
- 建议对高Lp(a) 个体的第一级亲属进行级联查.
结论:
- 测试脂蛋白[Lp[a]对于全面的ASCVD风险评估至关重要.
- 高Lp (a) 水平需要考虑冠状动脉评分和加强风险因素管理.
- 对于二次预防患者,在高Lp (a) 的情况下,可以考虑将PCSK9抑制添加到他类药物治疗中.
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