嗅觉功能障碍在过敏性鼻炎中的患病率和程度
Marco A Fornazieri1,2,3,4, Ellen C D Garcia1, Ricardo H Montero1
1Department of Surgery, Londrina State University, Londrina, Brazil.
American journal of rhinology & allergy
|May 17, 2024
概括
过敏性鼻炎 (AR) 显著增加了嗅觉功能障碍的流行率. 虽然AR影响气味,但它不能可靠地区分症状严重程度或过敏原类型,这表明潜在的OE变化需要更多的研究.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏学 过敏学
- 嗅觉研究 嗅觉研究
背景情况:
- 众所周知,过敏性鼻炎 (AR) 会影响气味,但患病率和影响严重程度尚不清楚.
- 现有研究显示,AR患者嗅觉功能障碍的患病率估计有所不同.
- 了解AR和嗅觉障碍之间的联系对于患者管理至关重要.
研究的目的:
- 量化AR患者的嗅觉功能障碍患病率.
- 评估嗅觉测试是否可以区分AR严重程度或ARIA分类.
- 调查过敏原对嗅觉和OE变化的特定影响.
主要方法:
- 在133名AR患者和100名对照人群中比较了嗅觉功能 (UPSIT®分数).
- 使用免疫光检测细胞标记物的嗅觉上皮质 (OE) 的检查.
- 分析了神经元活动,细胞亡,氧化应激和炎症的标志物.
主要成果:
- 复发性肺炎患者的嗅觉功能障碍率 (42.9%) 比对照组 (9%) 高得多.
- 根据AR持久性,严重程度或过敏原类型,没有发现嗅觉能力的显著差异.
- 趋势表明AR患者的OE中氨酸和cAMP的增加和降低,尽管在统计学上不显著.
结论:
- 嗅觉功能障碍在AR患者中更为普遍,但测试可能无法区分AR严重程度或特定过敏原敏感性.
- 新出现的证据表明,AR患者的OE可能存在病理生理学变化.
- 需要进一步的研究来确认OE变化及其对AR的临床影响.
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