环状微刺激通过减少对灵长类前-环状-状网络的自上而下的影响来诱导负面决策
Satoko Amemori1,2, Ann M Graybiel3, Ken-Ichi Amemori4
1Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Nature communications
|May 17, 2024
概括
研究人员通过刺激阴茎下环皮质来诱导灵长类动物在决策过程中产生负面偏差. 这种偏差与从背侧前额皮层 (dlPFC) 到边缘区域的功能连接性降低相关,表明上下情绪调节的丧失.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 灵长类动物研究研究
背景情况:
- 背侧前额皮层 (dlPFC) 在情绪调节中起着关键作用,对于预防抑郁症至关重要.
- 覆盖dlPFC和边缘区域的前额 - 脊柱 - 脊柱 (FCS) 网络与抑郁症中常见的负面评估偏见有关.
- 对于dlPFC对边缘系统的调节的精确机制尚未完全理解.
研究的目的:
- 调查决策中的负面评估偏见背后的神经机制.
- 探索FCS网络中的功能连接在情绪调节中的作用.
- 在非人类灵长类动物中模拟与抑郁相关的认知偏见的方面.
主要方法:
- 在冲突决策任务中对雌性灵长类动物的阴茎下带状皮层进行微刺激.
- 同时记录 fronto-cingulo-striatal (FCS) 局部场势 (LFPs) 的情况.
- 使用贝塔范围LFP的格兰杰因果关系来分析功能连接,以评估dlPFC与其他FCS区域之间的方向影响.
主要成果:
- 通过子阴带皮层刺激成功诱导了决策中的负面偏见.
- 观察到从认知dlPFC到边缘FCS区域的功能连接性显著下降.
- 在dlPFC的β范围LFP中显示了格兰杰因果关系的减少,这表明上下影响减少.
结论:
- 从认知到边缘区域的上下方向影响的丧失可能是抑郁症中看到的负面决策偏见的基础.
- 在FCS网络中的功能连接的改变与抑郁偏差的病理生理学有关.
- 这项研究提供了关于情绪失调和情感障碍中认知偏差的神经基础的见解.
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