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通过将向抗菌纳入抗瘤治疗中,实现了长期无复发的生存

Yuanlin Wang¹, Yaqian Han², Chenhui Yang¹

¹State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.

Nature communications

|May 17, 2024

概括

用新型抗菌剂向瘤居民细胞内微生物群 (TRIM) 可以抑制癌症生长并恢复抗瘤免疫力. 这种方法在临床前癌症模型中实现了长期无复发的生存.

科学领域:

在瘤学瘤学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

瘤内细胞微生物群 (TRIM) 在癌症发育中起作用.
用抗菌药物向TRIM对瘤抑制和瘤微环境 (TME) 内的免疫调节的影响尚不清楚.

研究的目的:

为了研究TRIM向抗菌的疗效与抗瘤疗法结合用于癌症治疗.
探索这种方法在恢复免疫监测和实现长期缓解方面的潜力.

主要方法:

开发一种结合Ag+释放,芬顿式反应和光热转换的单一剂,用于同时杀死细菌和多式抗瘤治疗.
利用乳腺癌和前列腺癌模型来评估该药物对瘤生长,免疫抑制和免疫反应的影响.
通过二次注射和远端瘤分析评估了长期无复发的生存率,免疫记忆和全身免疫反应.

主要成果:

开发的药物有效杀死细菌,并提供多式抗瘤疗法,解决TRIM诱导的免疫抑制和瘤过度生长.
恢复了抗瘤免疫监测和激活免疫反应,而不需要免疫刺激药物.
实现了超过700天的无复发生存,证明了持久的免疫记忆和全身免疫反应.

结论:

针对TRIM的抗菌对瘤抑制至关重要,并且可以克服与TME相关的免疫抑制.
这一策略为免疫调节提供了一条非常规的途径,也是通往彻底治愈癌症的潜在途径.
开发的药物对实现长期缓解和建立持久的抗瘤免疫力充满希望.

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