在乳腺癌中TGFβ诱导的上皮转移到介质细胞的综合分子相互作用图
Sai Bhavani Gottumukkala1, Trivadi Sundaram Ganesan2, Anbumathi Palanisamy3
1Department of Biotechnology, National Institute of Technology Warangal, Warangal, India.
NPJ systems biology and applications
|May 17, 2024
概括
这项研究绘制了导致转移性乳腺癌 (MBC) 进展的复杂信号通路. 了解这些途径,特别是TGFβ诱导的上皮层-介质细胞过渡 (EMT),为癌症转移提供了新的见解.
科学领域:
- 系统生物学 系统生物学
- 癌症研究 癌症研究
- 分子信号传递是分子信号传递.
背景情况:
- 转移性乳腺癌 (MBC) 是全球癌症死亡的主要原因.
- 表皮-介质细胞过渡 (EMT) 是癌细胞转移的一个关键过程.
- 转化生长因子-β (TGFβ) 信号与促进晚期乳腺癌中EMT有关.
研究的目的:
- 在MBC中构建TGFβ诱导的EMT的全面监管地图.
- 分析MBC进展背后的分子机制.
- 为了确定参与癌症转移的关键调节者.
主要方法:
- 广泛的文献调查,以建立一个生物网络.
- 使用系统生物学图形符号 (SBGN) 与细胞设计器.
- 使用CaSQ开发了一个布尔模型,并使用Cell Collective进行分析.
- 通过MINERVA公开的地图 (http://35.174.227.105:8080/minerva/?id=转移性_乳腺_癌_1).
主要成果:
- 组建了一个由312个物种和426个反应组成的网络,详细介绍了TGFβ诱导的EMT.
- 布尔模型模拟成功复制了已知的实验结果.
- 通过网络分析和转录组数据识别了关键枢纽监管机构.
- 证实了已识别的调节器在癌症转移中的作用.
结论:
- 开发的地图提供了TGFβ诱导的EMT促进MBC的信号相互作用的详细视图.
- 对地图的分析为MBC发展和进展提供了潜在的见解.
- 确定的枢纽监管机构需要进一步调查治疗策略.
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