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Updated: Jun 26, 2025

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
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为了更高阶的组合色素扰动而设计的CRISPR-Cas12a.

C C-S Hsiung1,2,3,4, C M Wilson2,3,4,5, N A Sambold4

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Nature biotechnology
|May 17, 2024
PubMed
概括

研究人员开发了一种新的CRISPR干扰 (CRISPRi) 工具,multiAsCas12a-KRAB,可以同时针对多个基因组位点. 这一进步促进了对遗传相互作用和调节元件功能的高效聚合查.

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