低益乳素和2型糖尿病之间的关系
Gie Ken-Dror1, David Fluck2, Michael E J Lean3
1Institute of Cardiovascular Research, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK.
Reviews in endocrine & metabolic disorders
|May 17, 2024
概括
低血清蛋白 (PRL) 水平与男性和女性2型糖尿病风险增加有关. 需要进一步的研究来了解在队列研究中观察到的男性与女性之间的不同关联.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 益生菌 (PRL) 是一种激素,在生殖过程中具有既定的作用,在高水平时已知有病理作用.
- 低循环PRL水平的临床意义仍然不太清楚.
- 2型糖尿病是一个主要的全球健康问题,具有复杂的促成因素.
研究的目的:
- 进行一项元分析,研究低益生素水平与2型糖尿病风险之间的关联.
- 综合来自横截面和队列研究的证据来评估这种关系.
主要方法:
- 五项横截面研究 (8,720名男性,3,429名女性) 和四项队列研究 (2,948名男性,3,203名女性) 的元分析.
- 排除患有影响PRL水平的疾病 (怀孕,哺乳期,高血,垂体疾病) 或服用相关药物的参与者.
- 按四分位数分类的PRL水平,在不同研究中具有不同的截止值.
- 2型糖尿病的诊断基于医生的诊断,禁食葡萄糖,OGTT或HbA1c.
主要成果:
- 截面研究显示,与最高水平相比,PRL水平最低的个体患2型糖尿病的几率显著更高 (男性:OR1.86,女性:OR2.15).
- 队列研究显示,低PRL和2型糖尿病在女性 (OR 1.52) 之间存在显著的关联,但在男性中没有 (OR 1.44).
- 异质性在横截面研究中较低 (I2 25-38.4%),但在队列研究中较高 (I2 52.8-79.7%).
结论:
- 循环中的低血清素水平与2型糖尿病的风险增加有关.
- 在队列研究中观察到的低PRL和男性与女性2型糖尿病之间的相关性差异需要进一步调查.
- 需要进一步的研究来澄清益乳素在2型糖尿病发病过程中的作用及其对性别的影响的差异.
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