相关实验视频
Updated: Jun 26, 2025

08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.1K
儿童和青少年炎症性肠病流行病学的变化
Dan Long1,2, Chenchen Wang2, Yingtao Huang3
1The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
International journal of colorectal disease
|May 17, 2024
概括
全球范围内,儿童和青少年的炎症性肠病 (IBD) 发病率正在上升,东亚和亚太地区的高收入地区出现了显著增加. 这一趋势强调IBD是一个日益严重的公共卫生问题,需要关注和制定政策.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 流行病学 流行病学
- 全球健康 全球健康
背景情况:
- 全球炎症性肠病 (IBD) 的发病率正在增加,但儿科流行病学数据仍然很少.
- 了解IBD在儿童和青少年的全球负担对于标准化护理和治疗策略至关重要.
研究的目的:
- 估计从1990年到2019年,IBD在儿科和青少年群体中的全球流行率和发病率.
- 分析年轻人的IBD负担的趋势和区域差异.
主要方法:
- 利用2019年全球疾病负担研究 (GBD 2019) 的综合数据进行横截面分析.
- 雇佣年龄标准化率 (ASR) 和估计年百分比变化 (EAPC) 来评估IBD负担和趋势.
主要成果:
- 2019年,全球新的IBD病例为25659例,儿童和青少年的流行病例为88829例,自1990年以来分别增加了22.8%和18.5%.
- 高社会人口指数 (SDI) 地区的IBD负担最高,东亚和高收入亚太地区的显著增加.
- 15-19岁年龄组的发病率和流行率较高,而5岁以下的年龄组显示出最显著的增加.
结论:
- 儿科和青少年IBD的发病率不断上升意味着公共卫生面临越来越大的挑战,这将对未来的医疗保健和经济产生重大影响.
- 全球,区域和国家IBD负担数据在年轻人群中将为制定有针对性的健康政策提供信息.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
219
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
219
Inflammatory Bowel Disease I: Ulcerative Colitis
166
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
166
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Chronic Bowel Disorders: Introduction
445
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
445
Inflammatory Bowel Disease IV: Pharmacological Management
126
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
126
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
115
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
115

