甘油三指数与美国成年人高尿血的非线性关联:一个横截面研究
Linjie Qiu1, Yan Ren1, Jixin Li1
1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Lipids in health and disease
|May 17, 2024
概括
甘油三糖 (TyG) 指数显示,在美国成年人中,反向U形与高尿路血的相关性. 较高的TyG指数水平最初会增加超尿血症的风险,然后在一个拐点之后降低.
科学领域:
- 代谢性疾病研究研究.
- 流行病学 流行病学
- 临床营养学 临床营养学
背景情况:
- 超尿血与代谢疾病有关,但与甘油三糖 (TyG) 指数的非线性关系尚未得到充分确立.
- 了解这种关联对于识别代谢性疾病风险因素至关重要.
研究的目的:
- 在美国成年人群中调查甘油三糖 (TyG) 指数和高尿血症之间的非线性关联.
- 为了确定这种关系中的潜在转折点.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2011-2018) 的横截面研究,共有8572名参与者.
- 三糖-葡萄糖 (TyG) 指数计算为Ln [三糖 × 禁食葡萄糖/2].
- 使用加权多重逻辑回归,通用增量模型和两部分线性回归来分析相关性.
主要成果:
- 在TyG指数和高尿血症之间发现了一个显著的反向U形非线性关联.
- 在TyG指数9.69的转折点被确定. 在这个点之前和之后的赔率 (OR) 分别为2.64 (2.12,3.28) 和0.32 (0.11,0.98).
- 在性别,BMI,高血压和糖尿病方面观察到有统计学意义的相互作用.
结论:
- 该研究表明,在美国成年人中,TyG指数和高尿素血症之间存在强烈的正相关性,具有复杂的非线性关系.
- 需要进一步的前性研究来证实这些发现及其临床影响.
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