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在致命的小鼠模型中,SARS-CoV-2原型和Omicron BA.1之间的致病性和中性粒细胞和单细胞反应的比较

Na Rong¹, Jing Wu¹, Binbin Zhao¹

¹NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.

Animal models and experimental medicine

|May 18, 2024

概括

SARS-CoV-2 Omicron BA.1比小鼠的原型菌株毒性较小,两种菌株都会导致类似的中性粒细胞和单细胞变化. 这项研究有助于理解COVID-19小鼠模型.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 已经产生了许多令人担忧的变体 (VOC).
欧米克朗BA.1.1变种在2021年底出现,在2022年初引起全球大流行.
现有的SARS-CoV-2致命性小鼠模型需要改进,不同菌株对免疫细胞的改变需要进一步研究.

研究的目的:

在人类ACE2转基因小鼠模型中比较SARS-CoV-2原型和Omicron BA.1菌株的致病性.
为了研究由这两种SARS-CoV-2菌株引起的中性粒细胞和单细胞的变化.

主要方法:

人类ACE2转基因小鼠感染了SARS-CoV-2原型或Omicron BA.1.
通过临床症状,病毒载量和组织病理学来评估致病性.
完整的血液样本,免疫组织化学和流动细胞计分析了中性粒细胞和单细胞的变化.

主要成果:

在小鼠模型中,Omicron BA.1的毒力明显低于SARS-CoV-2原型.
这两种菌株都导致中性粒细胞的晚期增加.
单细胞比例最初上升,然后下降,在两种菌株中观察到类似的趋势.

结论:

该研究验证了小鼠模型模拟严重的SARS-CoV-2原型和较轻的Omicron BA.1感染.
无论是SARS-CoV-2原型还是Omicron BA.1都在中性粒细胞和单细胞群中引起了类似的变化.

关键词:

欧米克朗BA.1 病毒在SARS-CoV-2中.动物模型动物模型一个单细胞单细胞.作为一个中性恋者.

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