心血管风险估计在艾滋病毒感染者中低于最佳
Virginia A Triant1,2,3,4, Asya Lyass5, Leo B Hurley6
1Division of General Internal Medicine Massachusetts General Hospital Boston MA.
已建立的心血管疾病 (CVD) 风险预测工具经常低估了艾滋病毒感染者的风险. 需要新的艾滋病毒特异性和性别特异性模型来改善心血管疾病风险评估和对艾滋病毒感染老年人的护理.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 已建立的心血管疾病 (CVD) 风险预测功能可能无法准确评估艾滋病毒感染者的风险.
- 这项研究评估了两种不同的艾滋病毒队列中三种常见的心血管疾病风险预测功能的表现.
研究的目的:
- 评估现有的CVD风险预测功能在HIV感染者中的准确性.
- 为了确定这些功能的表现,基于性别的潜在差异.
主要方法:
- 利用了来自马萨斯州布里格姆将军和凯泽永久北加利福尼亚艾滋病毒队伍的数据.
- 使用美国心脏病学会/美国心脏协会 (ACC/AHA) 动脉样硬化心脏病功能,弗雷明翰心脏研究 (FHS) 硬冠状动脉心脏病功能和FHS硬心脏病功能计算心脏病风险得分.
- 通过歧视 (c-统计) 和校准评估模型性能,将预测与观察到的风险按性别分层进行比较.
主要成果:
- 在9412名参与者中,1.7%经历了冠心病事件,3.3%经历了心血管疾病事件.
- 这三种功能都普遍低估了女性心血管疾病风险.
- 在男性中,两个功能低估了风险,而一个功能高估了风险. 校准对于具有一个功能的女性和具有所有功能的男性来说都很差.
- 歧视对女性来说是好的 (c-统计 0.78-0.90) 和适度的男性 (c-统计 0.71-0.72).
结论:
- 现有的心血管疾病风险预测功能往往低估了艾滋病毒感染者的风险.
- 模型性能的显著差异凸显了HIV特定和性别特定风险预测工具的必要性.
- 为艾滋病毒感染者开发量身定制的心血管疾病风险预测模型对于提高艾滋病毒感染老年人的护理至关重要.
更多相关视频
07:27Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Retrovirus Life Cycles
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Assessment of the Cardiovascular System I: Subjective Data
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
