根据种族和民族群体,评估糖基化血红蛋白值对心血管疾病的发展
Christopher G Low1, Maqdooda Merchant2, Yun-Yi Hung2
1Kaiser Permanente Medical Center Santa Clara CA.
Journal of the American Heart Association
|May 18, 2024
概括
预测心血管事件的糖化血红蛋白 (HbA1c) 值因种族和种族而异. 根据这些差异量身定制HbA1c目标对于有效的糖尿病和心血管疾病管理至关重要.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 人口健康 人口健康
背景情况:
- 糖尿病是心血管疾病 (CVD) 的主要危险因素.
- 糖化血红蛋白 (HbA1c) 水平表现出种族和民族差异.
- 目前糖尿病的诊断门缺乏针对CVD风险预测的种族和种族特异性考虑.
研究的目的:
- 调查预测主要不良心血管事件 (MACEs) 的糖化血红蛋白 (HbA1c) 值是否在种族和种族群体之间有所不同.
- 为评估心血管疾病风险建立种族和种族特定的HbA1c值.
主要方法:
- 对309,636名北加州Kaiser Permanente成年成员 (2014-2019) 的回顾性队列研究.
- 利用多变量后勤回归来分析菲律宾,南亚,东亚,黑人,白人和西班牙裔群体的MACE.
- 用于计算HbA1c值的员工Youden指数,按性别分层.
主要成果:
- 南亚种族显示MACE的几率最高 (OR 1.641).
- HbA1c积极预测的MACEs (或1.024每0.1%的增加).
- 确定了用于MACE预测的特定种族和性别的HbA1c值,其中几个群体低于典型的7.0%值.
结论:
- 研究结果表明,特定于种族和民族的HbA1c值对于准确估计心血管疾病风险至关重要.
- 考虑性别特定的HbA1c值可能是完善糖尿病治疗目标和心血管疾病风险管理策略所必需的.
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