阻塞性睡眠呼吸暂停综合征的严重程度与系统性免疫炎症指数之间是否存在关系?
Meltem Karacan Gölen1, Şaziye Melike Işık2, Veysel Arıkan3
1Department of Neurology, Baskent University Hospital Konya, Selcuklu, Konya, Turkey, 9042080. drmeltemkaracan@hotmail.com.
概括
系统性免疫炎症指数 (SII),中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 在阻塞性睡眠呼吸暂停综合征 (OSAS) 患者中升高. 这些炎症标志物与OSAS诊断有关,但与其严重程度无关.
科学领域:
- 睡眠医学 睡眠医学
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 病理生理学涉及血管功能障碍,氧化应激和全身炎症.
- 在OSAS中,呼吸暂停-呼吸暂停的发作被认为通过不和激活炎症途径.
研究的目的:
- 研究系统性炎症标志物 (SII,NLR,PLR) 与OSAS诊断和严重程度之间的关系.
- 评估这些炎症标志物在OSAS患者的诊断和预后价值.
主要方法:
- 171名OSAS患者根据他们的呼吸暂停-呼吸暂停指数 (AHI) 值进行分组.
- 在SII,NLR,PLR值和OSAS诊断/严重程度之间进行了相关性分析.
- 用完整血清测试来获得炎症标志物值.
主要成果:
- 与对照组相比,OSAS患者的NLR,PLR和SII值的平均值显著高于对照组.
- 在OSAS存在和SII值之间观察到18%的正相关性.
- 在SII,NLR和PLR值中没有发现关于OSAS严重性的统计学意义上的差异.
结论:
- SII,NLR和PLR独立地与OSAS诊断相关.
- 这些炎症标志物可以快速评估,并与OSAS相关.
- 在OSAS严重程度和研究的炎症标志物之间没有发现相关性.
相关概念视频
01:21Sleep Apnea
145
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
145
01:17Other Pulmonary Disorders
830
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
830
01:30Tonsillitis I: Introduction
236
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
236
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:13Insufficient Sleep and Sleep Deprivation
139
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
139