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一个与外体相关的lncRNA预后模型与肺腺癌的免疫微环境和治疗反应相关

Daifang Chu¹, Liulin Chen¹, Wangping Li²

¹Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Air Force Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China.

Clinical and experimental medicine

|May 18, 2024

概括

这项研究揭示了与外体相关的长非编码RNA (ER-lncRNAs) 作为肺腺癌 (LUAD) 的关键参与者. 与ER-lncRNA相关的风险评分 (ERS) 有效地预测患者的生存率,并为个性化治疗策略提供信息.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

外基因组和长非编码RNA (lncRNAs) 与癌症进展和耐药性有关.
外体相关 lncRNAs (ER-lncRNAs) 在肺腺癌 (LUAD) 中的特定作用需要进一步阐明.

研究的目的:

研究ER-lncRNAs在LUAD中的作用.
为LUAD患者开发基于ER-lncRNA的预后模型和风险评分.
在LUAD中探索ER-lncRNAs,免疫格局和药物敏感性之间的关系.

主要方法:

从TCGA-LUAD数据中分析与外体相关的mRNA和lncRNA表达特征.
单变Cox回归,共识聚类,GSEA和功能丰富分析.
构建一个与ER-lncRNA相关的预后模型和风险评分 (ERS),在多个队列中得到验证.

主要成果:

确定了134个差异表达的ER-lncRNAs,其中19个与LUAD预后有显著的关联.
开发了一种与ER-lncRNA相关的预后模型和风险评分 (ERS),可以预测整体存活率.
在高和低ERS组之间观察到不同的免疫格局和差异性的药物敏感性.
实验验证证了提米丁激酶1促进LUAD入侵和转移.

结论:

与ER-lncRNA相关的风险评分 (ERS) 作为LUAD的独立预后因素.
基于ERS的风险分层可以指导LUAD患者的个性化治疗策略.
ER-lncRNAs代表了LUAD的潜在治疗点和生物标志物.

关键词:

异构体是什么? 异构体是什么? 外构体是什么?长的非编码RNA是什么?肺部腺癌瘤是肺部腺癌.预测模型是一个预测模型.瘤的免疫微环境

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