通过Stevia rebaudiana提取物进行铜纳米颗粒生物合成:生物相容性和抗菌应用
Mostafa Fathi Abdelhai1, Romisaa H Shabaan1, Noha M Kamal1
1Biotechnology Program, Faculty of Agriculture, Ain Shams University, Shubra El-Khaimah, Cairo, 11241, Egypt.
AMB Express
|May 18, 2024
概括
研究人员开发了一种环保方法,使用Stevia rebaudiana提取物合成铜纳米粒子 (CuNPs). 这些生物合成的CuNPs对细菌和真菌具有显著的抗菌活性,为抗药性多种生物体提供了抗生素的潜在替代品.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物技术是生物技术.
背景情况:
- 对先进材料的需求需要纳米颗粒的新型合成方法.
- 铜纳米粒子 (CuNPs) 在各种应用中至关重要,需要高效和可持续的生产技术.
研究的目的:
- 开发一种简单,生态和良性工艺,使用Stevia rebaudiana (糖果叶) 水性提取物合成铜纳米粒子 (CuNPs).
- 描述生物合成的CuNPs并评估它们的抗微生物和细胞毒性.
主要方法:
- 铜纳米颗粒是使用Stevia rebaudiana叶子提取物合成的.
- 描述涉及紫外线可见光谱,DLS,XRD,HR-TEM,FTIR和泽塔潜力分析.
- 对八种细菌和五种真菌菌株进行了抗菌活性测试.
- 细胞毒性被评估以确定安全性和有效性.
主要成果:
- 鉴定证实了球形-CuNPs (51.46-53.17 nm) 的形成,平均直径为362.3 nm,泽塔电位为-10.8 mV.
- -CuNPs表现出显著的抗菌活性,特别是针对金黄色葡萄球菌和黄菌.
- 这些纳米颗粒表现出一种杀菌/杀菌作用模式,其最小抑制和致命度较低.
结论:
- 生物合成的-CuNPs提供了可持续和有效的抗菌剂.
- 这些CuNPs显示出作为传统抗生素的替代品,用于对抗多药耐药微生物的承诺.
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